Endocrine Abstracts

Introduction: Acromegaly is associated with skeletal changes that are characterized by appositional bone growth, increased bone dimensions and increased bone turnover. PTH is an important regulator of bone remodeling and its anabolic action requires the presence of GH. The strong correlation found between PTH concentrations and bone turnover markers in active and treated acromegaly has led to the suggestion, that the effect of GH on bone turnover may be mediated by PTH. Succes...